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Shield Therapeutics reports 54% growth in ACCRUFeR sales, but warns over impact of Medicaid changes

Shield Therapeutics reported Q1 2026 net revenue of $18m and positive EBIT of c.$2.5m, driven by a $7.9m development milestone and 54% growth in its ACCRUFeR® franchise.
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The Premarket Brief: AstraZeneca, Pearson, NatWest, Santander UK, Lansdowne Oil & Gas, Total Graphite, Active Energy Group, Union Jack Oil, accesso Technology Group
This overhead photograph features a large rectangular table displaying an organized grid of pint glasses filled with varying levels of amber liquid. The glasses, some full, some half-empty, and others drained, resemble a bar chart that abstractly represents volume and consumption patterns in a bar setting, while the table's dark wood-effect surface adds a familiar and warm ambiance.

Total Graphite to update Montepuez DFS and VES as it reworks project economics
The image features three stacks of new King Charles pound coins, arranged in ascending height. The tallest stack leans slightly, with the top coin illuminated by a warm spotlight, creating a striking visual against a dark slate surface. The coins' intricate milled edges and twelve-sided design are highlighted, suggesting themes of accumulation and growth.

Active Energy to raise £1.3m to fund Middle East digital-asset infrastructure
The image depicts the exterior corner of a modern Santander bank branch at dusk, showcasing a bright red backlit canopy that illuminates the wet pavement beneath. The glass entrance door reveals a sparsely furnished interior with cool white lighting and a wilting poinsettia, while a single abandoned black umbrella leans against the wall, capturing the stillness after a recent rain.

Santander UK completes £2.86bn cash acquisition of TSB
A person is using an ATM machine outside a bank. The ATM is branded with the logo of NatWest and features bright purple signage. The individual is engaged in a transaction at the machine.

NatWest raises 2026 income guidance to top end of range after strong Q1

NatWest Group now expects 2026 income to be at the top end of its previously guided £17.2-17.6bn range, citing its latest interest rate and economic assumptions.
The image shows a construction site with a white hard hat, reflective safety vest, blueprints, and a clipboard on a wooden surface. In the background, construction workers are visible alongside a crane and the partially constructed building framework.

ProService flags FY26 revenue miss as Speedy Hire ramp-up lags
The image captures a private equity boardroom setting in Berlin's Mitte district, featuring a long wooden table set for a formal presentation. A founder and CTO are engaged in a discussion with a senior partner, with multiple documents laid out for signing and business cards exchanged on the table, accompanied by a half-eaten pastry and laptops showing financial models.

TEAM completes EPIC Guernsey takeover
The image captures the interior view of a drilling derrick tower, looking directly upward. The structure's intricate steel lattice forms a geometric pattern converging toward the crown block, silhouetted against a pale overcast sky, while drilling equipment and pipe racks embellish the sides, revealing an industrial environment characterized by heavy machinery.

Union Jack Oil says Crossroads spud delayed as rig remains under maintenance

Union Jack Oil's planned spud of the Crossroads Well in southern Oklahoma has been postponed while the rig undergoes maintenance, with a spud date to be provided in early May.
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accesso appoints Lee Cowie as its new CEO

accesso Technology Group has appointed Lee Cowie as Chief Executive Officer with effect from 1 May, and Steve Brown has stepped down as Chief Executive Officer and as a Director while remaining available to the Board during a handover.
The image showcases a green moss-covered wall featuring the logo of the pharmaceutical company AstraZeneca. The natural elements create a calming environment that reflects a modern and eco-friendly design approach.

AstraZeneca's Truqap recommended by FDA advisory panel for a form of prostate cancer

The FDA panel agreed that Truqap (capivasertib) plus abiraterone and ADT has a favourable benefit‑risk profile for a form of prostate cancer.
The image depicts the exterior of the AstraZeneca headquarters, showcasing a prominent logo displayed on the building's facade. The area is landscaped with greenery, providing a modern and inviting atmosphere.

AstraZeneca fails to win FDA advisory backing for camizestrant

An FDA Oncologic Drugs Advisory Committee voted 3-6 and did not reach a majority in favour of the benefit-risk profile for camizestrant combined with a CDK4/6 inhibitor in first-line HR-positive, HER2‑negative advanced breast cancer.
The image shows a geologist's gloved hand holding a fresh rock sample that displays bright native silver with wire-like metallic threads, alongside tarnished grey-black argentite embedded in a white calcite vein. The specimen's metallic luster is accentuated by hard sunlight, while the background remains softly focused, enhancing the tactile quality of the geological find.

Mining Today: South32, Ajax Resources, New Frontier, First Tin, Alba, Kefi, Glencore, Blencowe, Iofina, Kazera
The image features a close-up of a semiconductor chip placed on a stack of gold coins. This composition visually symbolizes the intersection of technology and finance, highlighting the value of technological advancements.

Tech Today: Built Cybernetics, Visum, Weir Group, Sage, ZOO Digital

A dilutive fundraise hammers Built Cybernetics to the bottom of the leaderboard, while a broad sweep of trading updates and strategic pivots keeps the session busy across tech and tech-adjacent names. Elsewhere, a modular edge AI repositioning from Visum.
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Deutsche Bank downgrades Haleon, cautions over lack of innovation
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Jet2 downgraded as DB accounts for softening demand since start of Iran conflict
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Panmure Liberum eyes 'strategic pivot' at BUY rated Whitbread

Panmure Liberum rates Whitbread BUY with a 3,440p price target after the Premier Inn owner extended its five‑year plan to FY31 and flagged a full exit from branded restaurants plus additional sale‑and‑leasebacks.
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Persimmon is building momentum despite tough market says analyst

Persimmon's early‑2026 sales and order‑book gains underpin maintained completion guidance and support current profit expectations.
The image depicts a small green sprout emerging from a cracked, weathered brick. The contrasting elements of the natural plant and the aged brick symbolize growth and resilience.

Are retail investors losing interest in ESG?

Tara Irwin, senior ESG analyst at Hargreaves Lansdown, says a December 2025 survey finds retail prioritisation of climate falling even as expectations of institutional action and scrutiny of banks rise.
The image features a close-up view of a 20 Euro banknote alongside a collection of Euro coins. The backdrop includes a partially visible wallet, suggesting a financial or economic context.

The ECB has left the door open for a June hike

Mark Wall, Chief European Economist at Deutsche Bank, says that although the ECB left policy rates unchanged there are symmetric upside risks to inflation and downside risks to growth, keeping the option of a June increase alive.